The Functional Consequences of Relative Substrate Specificity in Complex Biochemical Systems
نویسندگان
چکیده
منابع مشابه
The Functional Consequences of Relative Substrate Specificity in Complex Biochemical Systems
A biochemical activity, that is, enzymatic reaction or molecular interaction, frequently involves a molecule, for example, an enzyme, capable of interacting with numerous substrates or partners. Specificity is a fundamental property of biochemical activities, and relative specificity refers to the situation whereby a molecule interacts with multiple substrates or partners but with different aff...
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The investigation of the substrate specificity of the pyruvate dehydrogenase complex from Escherichia coli allows a description of the binding region of pyruvate. Substrate analogs with electronegative substitutions in the methyl group show a strong competitive inhibition of the overall reaction of the pyruvate dehydrogenase complex. The most efficient inhibitor is fluoropyruvate which has a mo...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2011
ISSN: 1664-8021
DOI: 10.3389/fgene.2011.00065